The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.
Identifieur interne : 000275 ( Main/Exploration ); précédent : 000274; suivant : 000276The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.
Auteurs : Simon D. Harding [Royaume-Uni] ; Joanna L. Sharman [Royaume-Uni] ; Elena Faccenda [Royaume-Uni] ; Chris Southan [Royaume-Uni] ; Adam J. Pawson [Royaume-Uni] ; Sam Ireland [Royaume-Uni] ; Alasdair J G. Gray [Royaume-Uni] ; Liam Bruce [Royaume-Uni] ; Stephen P H. Alexander [Royaume-Uni] ; Stephen Anderton [Royaume-Uni] ; Clare Bryant [Royaume-Uni] ; Anthony P. Davenport [Royaume-Uni] ; Christian Doerig [Australie] ; Doriano Fabbro [Suisse] ; Francesca Levi-Schaffer [Israël] ; Michael Spedding [France] ; Jamie A. Davies [Royaume-Uni]Source :
- Nucleic acids research [ 1362-4962 ] ; 2017.
Abstract
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes ∼9000 ligands, ∼15 000 binding constants, ∼6000 papers and ∼1700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been 'forked' from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.
DOI: 10.1093/nar/gkx1121
PubMed: 29149325
Affiliations:
- Australie, France, Israël, Royaume-Uni, Suisse
- Angleterre, Angleterre de l'Est, Grand Londres, Écosse, Île-de-France
- Cambridge, Londres, Édimbourg
- University College de Londres, Université d'Édimbourg, Université de Cambridge
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000002
- to stream PubMed, to step Curation: 000002
- to stream PubMed, to step Checkpoint: 000002
- to stream Ncbi, to step Merge: 005230
- to stream Ncbi, to step Curation: 005230
- to stream Ncbi, to step Checkpoint: 005230
- to stream Main, to step Merge: 000270
- to stream Main, to step Curation: 000275
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.</title><author><name sortKey="Harding, Simon D" sort="Harding, Simon D" uniqKey="Harding S" first="Simon D" last="Harding">Simon D. Harding</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sharman, Joanna L" sort="Sharman, Joanna L" uniqKey="Sharman J" first="Joanna L" last="Sharman">Joanna L. Sharman</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Faccenda, Elena" sort="Faccenda, Elena" uniqKey="Faccenda E" first="Elena" last="Faccenda">Elena Faccenda</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Southan, Chris" sort="Southan, Chris" uniqKey="Southan C" first="Chris" last="Southan">Chris Southan</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Pawson, Adam J" sort="Pawson, Adam J" uniqKey="Pawson A" first="Adam J" last="Pawson">Adam J. Pawson</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Ireland, Sam" sort="Ireland, Sam" uniqKey="Ireland S" first="Sam" last="Ireland">Sam Ireland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural & Molecular Biology, University College London, London WC1E 6BT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Structural & Molecular Biology, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gray, Alasdair J G" sort="Gray, Alasdair J G" uniqKey="Gray A" first="Alasdair J G" last="Gray">Alasdair J G. Gray</name><affiliation wicri:level="1"><nlm:affiliation>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, Liam" sort="Bruce, Liam" uniqKey="Bruce L" first="Liam" last="Bruce">Liam Bruce</name><affiliation wicri:level="1"><nlm:affiliation>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Alexander, Stephen P H" sort="Alexander, Stephen P H" uniqKey="Alexander S" first="Stephen P H" last="Alexander">Stephen P H. Alexander</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH</wicri:regionArea><wicri:noRegion>Nottingham NG7 2UH</wicri:noRegion></affiliation></author><author><name sortKey="Anderton, Stephen" sort="Anderton, Stephen" uniqKey="Anderton S" first="Stephen" last="Anderton">Stephen Anderton</name><affiliation wicri:level="4"><nlm:affiliation>MRC Centre for inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bryant, Clare" sort="Bryant, Clare" uniqKey="Bryant C" first="Clare" last="Bryant">Clare Bryant</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Davenport, Anthony P" sort="Davenport, Anthony P" uniqKey="Davenport A" first="Anthony P" last="Davenport">Anthony P. Davenport</name><affiliation wicri:level="4"><nlm:affiliation>Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2?0QQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2?0QQ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Monash University, Clayton 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, Monash University, Clayton 3800</wicri:regionArea><wicri:noRegion>Clayton 3800</wicri:noRegion></affiliation></author><author><name sortKey="Fabbro, Doriano" sort="Fabbro, Doriano" uniqKey="Fabbro D" first="Doriano" last="Fabbro">Doriano Fabbro</name><affiliation wicri:level="1"><nlm:affiliation>PIQUR Therapeutics, Basel 4057, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>PIQUR Therapeutics, Basel 4057</wicri:regionArea><wicri:noRegion>Basel 4057</wicri:noRegion></affiliation></author><author><name sortKey="Levi Schaffer, Francesca" sort="Levi Schaffer, Francesca" uniqKey="Levi Schaffer F" first="Francesca" last="Levi-Schaffer">Francesca Levi-Schaffer</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 9112102</wicri:regionArea><wicri:noRegion>Jerusalem 9112102</wicri:noRegion></affiliation></author><author><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name><affiliation wicri:level="3"><nlm:affiliation>Spedding Research Solutions SAS, Le Vésinet 78110, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Spedding Research Solutions SAS, Le Vésinet 78110</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Davies, Jamie A" sort="Davies, Jamie A" uniqKey="Davies J" first="Jamie A" last="Davies">Jamie A. Davies</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:29149325</idno><idno type="pmid">29149325</idno><idno type="doi">10.1093/nar/gkx1121</idno><idno type="wicri:Area/PubMed/Corpus">000002</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000002</idno><idno type="wicri:Area/PubMed/Curation">000002</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000002</idno><idno type="wicri:Area/PubMed/Checkpoint">000002</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000002</idno><idno type="wicri:Area/Ncbi/Merge">005230</idno><idno type="wicri:Area/Ncbi/Curation">005230</idno><idno type="wicri:Area/Ncbi/Checkpoint">005230</idno><idno type="wicri:Area/Main/Merge">000270</idno><idno type="wicri:Area/Main/Curation">000275</idno><idno type="wicri:Area/Main/Exploration">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.</title><author><name sortKey="Harding, Simon D" sort="Harding, Simon D" uniqKey="Harding S" first="Simon D" last="Harding">Simon D. Harding</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Sharman, Joanna L" sort="Sharman, Joanna L" uniqKey="Sharman J" first="Joanna L" last="Sharman">Joanna L. Sharman</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Faccenda, Elena" sort="Faccenda, Elena" uniqKey="Faccenda E" first="Elena" last="Faccenda">Elena Faccenda</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Southan, Chris" sort="Southan, Chris" uniqKey="Southan C" first="Chris" last="Southan">Chris Southan</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Pawson, Adam J" sort="Pawson, Adam J" uniqKey="Pawson A" first="Adam J" last="Pawson">Adam J. Pawson</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Ireland, Sam" sort="Ireland, Sam" uniqKey="Ireland S" first="Sam" last="Ireland">Sam Ireland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Structural & Molecular Biology, University College London, London WC1E 6BT, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Structural & Molecular Biology, University College London, London WC1E 6BT</wicri:regionArea><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Gray, Alasdair J G" sort="Gray, Alasdair J G" uniqKey="Gray A" first="Alasdair J G" last="Gray">Alasdair J G. Gray</name><affiliation wicri:level="1"><nlm:affiliation>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Bruce, Liam" sort="Bruce, Liam" uniqKey="Bruce L" first="Liam" last="Bruce">Liam Bruce</name><affiliation wicri:level="1"><nlm:affiliation>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS</wicri:regionArea><wicri:noRegion>Edinburgh EH14 4AS</wicri:noRegion></affiliation></author><author><name sortKey="Alexander, Stephen P H" sort="Alexander, Stephen P H" uniqKey="Alexander S" first="Stephen P H" last="Alexander">Stephen P H. Alexander</name><affiliation wicri:level="1"><nlm:affiliation>School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Life Sciences, University of Nottingham Medical School, Nottingham NG7 2UH</wicri:regionArea><wicri:noRegion>Nottingham NG7 2UH</wicri:noRegion></affiliation></author><author><name sortKey="Anderton, Stephen" sort="Anderton, Stephen" uniqKey="Anderton S" first="Stephen" last="Anderton">Stephen Anderton</name><affiliation wicri:level="4"><nlm:affiliation>MRC Centre for inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>MRC Centre for inflammation Research, University of Edinburgh, Edinburgh EH16 4TJ</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author><author><name sortKey="Bryant, Clare" sort="Bryant, Clare" uniqKey="Bryant C" first="Clare" last="Bryant">Clare Bryant</name><affiliation wicri:level="4"><nlm:affiliation>Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Davenport, Anthony P" sort="Davenport, Anthony P" uniqKey="Davenport A" first="Anthony P" last="Davenport">Anthony P. Davenport</name><affiliation wicri:level="4"><nlm:affiliation>Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2?0QQ, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB2?0QQ</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name><affiliation wicri:level="1"><nlm:affiliation>Department of Microbiology, Monash University, Clayton 3800, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology, Monash University, Clayton 3800</wicri:regionArea><wicri:noRegion>Clayton 3800</wicri:noRegion></affiliation></author><author><name sortKey="Fabbro, Doriano" sort="Fabbro, Doriano" uniqKey="Fabbro D" first="Doriano" last="Fabbro">Doriano Fabbro</name><affiliation wicri:level="1"><nlm:affiliation>PIQUR Therapeutics, Basel 4057, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>PIQUR Therapeutics, Basel 4057</wicri:regionArea><wicri:noRegion>Basel 4057</wicri:noRegion></affiliation></author><author><name sortKey="Levi Schaffer, Francesca" sort="Levi Schaffer, Francesca" uniqKey="Levi Schaffer F" first="Francesca" last="Levi-Schaffer">Francesca Levi-Schaffer</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.</nlm:affiliation><country xml:lang="fr">Israël</country><wicri:regionArea>Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem 9112102</wicri:regionArea><wicri:noRegion>Jerusalem 9112102</wicri:noRegion></affiliation></author><author><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name><affiliation wicri:level="3"><nlm:affiliation>Spedding Research Solutions SAS, Le Vésinet 78110, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Spedding Research Solutions SAS, Le Vésinet 78110</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Davies, Jamie A" sort="Davies, Jamie A" uniqKey="Davies J" first="Jamie A" last="Davies">Jamie A. Davies</name><affiliation wicri:level="4"><nlm:affiliation>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deanery of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD</wicri:regionArea><orgName type="university">Université d'Édimbourg</orgName><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region></placeName></affiliation></author></analytic><series><title level="j">Nucleic acids research</title><idno type="eISSN">1362-4962</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, www.guidetopharmacology.org) and its precursor IUPHAR-DB, have captured expert-curated interactions between targets and ligands from selected papers in pharmacology and drug discovery since 2003. This resource continues to be developed in conjunction with the International Union of Basic and Clinical Pharmacology (IUPHAR) and the British Pharmacological Society (BPS). As previously described, our unique model of content selection and quality control is based on 96 target-class subcommittees comprising 512 scientists collaborating with in-house curators. This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015. Our relationship matrix now describes ∼9000 ligands, ∼15 000 binding constants, ∼6000 papers and ∼1700 human proteins. As an important addition, we also introduce our newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org). This has been 'forked' from the well-established GtoPdb data model and expanded into new types of data related to the immune system and inflammatory processes. This includes new ligands, targets, pathways, cell types and diseases for which we are recruiting new IUPHAR expert committees. Designed as an immunopharmacological gateway, it also has an emphasis on potential therapeutic interventions.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Israël</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Grand Londres</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Cambridge</li><li>Londres</li><li>Édimbourg</li></settlement><orgName><li>University College de Londres</li><li>Université d'Édimbourg</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Harding, Simon D" sort="Harding, Simon D" uniqKey="Harding S" first="Simon D" last="Harding">Simon D. Harding</name></region><name sortKey="Alexander, Stephen P H" sort="Alexander, Stephen P H" uniqKey="Alexander S" first="Stephen P H" last="Alexander">Stephen P H. Alexander</name><name sortKey="Anderton, Stephen" sort="Anderton, Stephen" uniqKey="Anderton S" first="Stephen" last="Anderton">Stephen Anderton</name><name sortKey="Bruce, Liam" sort="Bruce, Liam" uniqKey="Bruce L" first="Liam" last="Bruce">Liam Bruce</name><name sortKey="Bryant, Clare" sort="Bryant, Clare" uniqKey="Bryant C" first="Clare" last="Bryant">Clare Bryant</name><name sortKey="Davenport, Anthony P" sort="Davenport, Anthony P" uniqKey="Davenport A" first="Anthony P" last="Davenport">Anthony P. Davenport</name><name sortKey="Davies, Jamie A" sort="Davies, Jamie A" uniqKey="Davies J" first="Jamie A" last="Davies">Jamie A. Davies</name><name sortKey="Faccenda, Elena" sort="Faccenda, Elena" uniqKey="Faccenda E" first="Elena" last="Faccenda">Elena Faccenda</name><name sortKey="Gray, Alasdair J G" sort="Gray, Alasdair J G" uniqKey="Gray A" first="Alasdair J G" last="Gray">Alasdair J G. Gray</name><name sortKey="Ireland, Sam" sort="Ireland, Sam" uniqKey="Ireland S" first="Sam" last="Ireland">Sam Ireland</name><name sortKey="Pawson, Adam J" sort="Pawson, Adam J" uniqKey="Pawson A" first="Adam J" last="Pawson">Adam J. Pawson</name><name sortKey="Sharman, Joanna L" sort="Sharman, Joanna L" uniqKey="Sharman J" first="Joanna L" last="Sharman">Joanna L. Sharman</name><name sortKey="Southan, Chris" sort="Southan, Chris" uniqKey="Southan C" first="Chris" last="Southan">Chris Southan</name></country><country name="Australie"><noRegion><name sortKey="Doerig, Christian" sort="Doerig, Christian" uniqKey="Doerig C" first="Christian" last="Doerig">Christian Doerig</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Fabbro, Doriano" sort="Fabbro, Doriano" uniqKey="Fabbro D" first="Doriano" last="Fabbro">Doriano Fabbro</name></noRegion></country><country name="Israël"><noRegion><name sortKey="Levi Schaffer, Francesca" sort="Levi Schaffer, Francesca" uniqKey="Levi Schaffer F" first="Francesca" last="Levi-Schaffer">Francesca Levi-Schaffer</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Spedding, Michael" sort="Spedding, Michael" uniqKey="Spedding M" first="Michael" last="Spedding">Michael Spedding</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000275 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000275 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:29149325
|texte= The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:29149325" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |